Sottile Lab

 

Stem Cell Biology & Cell Differentiation

Our Research:

 

ii) Characterising the regulation of neural stem cells, which reside in discrete locations in the adult brain:

Using a range of models, we study the distribution, properties and gene expression pattern of neural stem cells to determine the core features defining these progenitors. We are also interested in elucidating the relationship between stem cells, tissue repair and neoplasia.

 

Previous studies carried out in our lab have shown that the expression of Sox1 and Sox2, two markers associated with neural stem cells, are also found in a discrete cell population of cerebellum.

Our recent publication in Cell Research shows that these cells exhibit stem cell characteristics when isolated in culture.

We are currently carrying out further experiments to better characterise this cell population, understand its role in cerebellar physiology, and evaluate its relevance to cerebellar damage.

 

 

Our latest study makes the cover of Cell Research:

 

 

 

 

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Page last updated Dec. 2009

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