Sottile Lab

 

Stem Cell Biology & Cell Differentiation

Our Research:

Our group focuses on the genetic aspects of stem cell biology, and on the molecular mechanisms regulating the differentiation ability of stem cells from adult and embryonic origin. We isolate, grow and study stem cells from different sources, in order to:

i) investigate the signalling pathways and genetic machinery regulating the differentiation potential of mesenchymal stem cells towards mesenchymal (osteo/adipogenic) and extra-mesenchymal lineages, using in vitro culture, gene manipulation and differentiation.

ii) characterise the regulation of neural stem cells, which reside in discrete locations in the adult brain. Using a range of models, we study the distribution, properties and gene expression pattern of neural stem cells to determine the core features defining these progenitors. We are also interested in elucidating the relationship between stem cells, tissue repair and neoplasia.

 

See our latest study on the cover of Cell Research:

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Page last updated Dec. 2009

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